Une femme de 80 ans, traitée par méthotrexate (MTX) et TCZ pour une PR, présentait une dermo-hypodermite de jambe gauche 8jours après une 13 e. Allergic reactions are a product of inappropriately triggered inflammation responses by mast cells to allergens. Such hypersensitivity responses are controlled by. MOTS CLES: Erysipèle – Facteur de risque – Erysipèle de jambe. JURY 4 patients (13,3%) avaient à l’examen clinique des varices des membres inférieurs.
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This treatment is extremely effective in rheumatoid arthritis RAwhich may well be accompanied by serious infections presenting misleading clinical pictures.
Herein we report a case of a typical bacterial dermo-hypodermitis in a female patient treated with TCZ. She exhibited neither fever nor biological inflammatory syndrome.
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Two weeks later, the patient was apyretic and her laboratory results were normal, although local inflammatory signs persisted. Subsequent courses of TCZ were administered without incident.
During the course of treatment with TCZ, this patient presented delineated bacterial cellulitis in the form of erysipelas, which was noteworthy on account of the absence of fever and of biological inflammatory syndrome.
While there have been reports of severe cases of cellulitis during TCZ treatment, to our knowledge, there have been none of erysipelas. Attenuation of local and systemic inflammatory symptoms is widely reported, and is directly associated with the anti-IL-6 action of TCZ. Patients with RA are especially susceptible to opportunistic or severe infections as a result of the disease itself and of associated treatments, and increased vigilance is called for with regard to infections that may be transformed and potentially more severe as a result of TCZ.
Tocilizumab, Interleukin-6, Rheumatoid arthritis, Erysipelas, Cellulitis. Journal page Archives Contents list. Feuilhade de Chauvin, A. Access to the text HTML. Access to the PDF text. Access to the full text of this article requires a subscription. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen. If you want to subscribe to this journal, see our rates You can purchase this item in Pay Per View: Erysipelas without fever or biologic inflammation during tocilizumab therapy.
Henry bN. Petitpain aJ. Schmutz bP. Outline Masquer le plan. Top of the page – Article Outline.
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