ERGOT AND ERGOTISM PDF

Poisoning attributed to Ergot of Rye is referred to as ergotism. Although this fungus is recognized as one species, there are two sets of symptoms that can be . Editorial from The New England Journal of Medicine — Ergot and Ergotism. LSD is a derivative of ergot, a fungus that affects rye grain. Ergotism — ergot poisoning — had indeed been implicated in other outbreaks of bizarre behavior, .

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A case of ergotism is presented to illustrate the role of duplex ultrasonography in the diagnosis and management of this nonatherosclerotic cause of peripheral arterial disease. Historical aspects of ergotism are discussed together with reference to the relative vulnerability of different segments of the arterial circulation.

Ergot Ergotism – Bugwoodwiki

Our case emphasizes the potential for complete reversibility of the vascular changes if recognized early. The vast majority of patients with peripheral arterial disease have atherosclerosis. A small number are caused by thrombotic disorders, thromboembolism, or inflammatory arterial diseases. Even rarer, with an incidence rate of 0. Ergotism is a potentially reversible disease process which needs to be considered in the differential diagnosis of patients with peripheral lower limb ischemia especially if there is a lack of classical risk factors for atherosclerosis.

This case presentation and review of the literature aims to grasp the complexity of this rare disease process as well as demonstrating the pivotal role of duplex ultrasonography in the diagnosis and management of patients who are affected by ergotism.

A year-old female patient presented with a month history of classical severe lower limb symptoms of intermittent claudication.

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Her eergotism history was unremarkable and notable for absence of classical risk factors for atherosclerosis; she was fit and healthy with normal blood pressure and heart rate recordings, and there was no history of diabetes, smoking or Raynaud phenomenon. However, the patient did have a long history of migraine, which had been treated with both caffeine—ergotamine tartrate and methysergide.

On erogtism examination, the common femoral artery pulses were reduced bilaterally and accompanied by bruits. She was referred to a ertotism vascular laboratory for duplex ultrasound study of the abdominal aorta, iliac, and femoral arteries. There was no accompanying calcification or other evidence of an atherosclerotic process. The abdominal aorta appeared normal. The results of the duplex ultrasound study strongly suggested a nonatherosclerotic cause, and given the patients’ medical history, the possibility of ergotism.

The patient was instructed to cease all migraine medication and both aspirin and a calcium channel blocker were prescribed to prevent any thrombotic complications and to promote vasodilation.

A repeat duplex ultrasound study of the abdominal aorta, iliac, and lower limb arteries were performed at 3 weeks and again at 4 months after diagnosis.

At 3 weeks, there was a significant improvement in ergotusm diameter of the affected segments. At 4 months, the external iliac arteries had returned to normal luminal diameter, with normal ergottism blood flow velocities.

There were no residual symptoms.

This complete recovery without any other intervention confirmed the diagnosis of ergotism. The patient had no residual symptoms of intermittent claudication as the cessation of the migraine medication is not requiring any treatment for migraine at the present Fig. Color Doppler images of the right and left external iliac arteries over 4-month time frame.

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Ergot is the more common name of the sclerotia of srgotism fungal species, from within the genus of Claviceps purpureawhich produces ergot alkaloids.

Clues and Evidence

Ergotism occurs when either the fungus is ingested via the contamination of grain, for example, rye, or by the medicinal use of drugs derived from ergotamine compounds. Anthony fire occurred in medieval times as a consequence of this fungal contamination in grain. In recent times, medications containing ergot alkaloids have been used in the treatment of migraine, vascular headaches, and control of postpartum hemorrhage.

Some of the earliest documented medicinal uses of ergot preparations were for childbirth. There is documented evidence from as early as the s that ergot derivatives were used to accelerate labor, prevent postpartum hemorrhage, and in some cases to induce abortion in the early stages of pregnancy 4 5 Fig.

Ergot of rye, the sclerotium. In addition, an important potential consequence of intense protracted vasospasm is the loss of endothelial integrity and thereby increased risk of thrombosis and irreversible ischemia. Furthermore, loss of the endothelium exposes the unprotected vascular smooth muscle to circulating catecholamines and other vasoactive amines and autacoids. There is also the risk of fibrosis of the vessel wall secondary to constriction of the vasa vasora.

Ergot alkaloids are primarily metabolized by the liver and specifically by a subgroup of the cytochrome P isoenzyme CYP3A4, and are excreted in the feces via biliary elimination with a small fraction excreted through the kidneys.

The formulation most associated with medicinal-induced ergotism is the ergotamine—caffeine suppository. Rectal absorption is directed toward the liver, and with the addition of caffeine, ergotamine metabolism is inhibited. Arterial vasospasm or vasoconstriction resulting from ergot consumption can affect any blood vessel in the body, however, the lower limbs are most commonly affected. The direct vasoconstrictive effect that is associated with ergotism curiously targets medium-sized vessels, notably the external iliac artery and the superficial femoral artery.

Considering the arterial wall, the question arises as to whether the ratio of collagen to elastin or the ratio of vascular smooth muscle to connective tissue is a factor in the specific selection of these arteries in regards to ergotism.

The ratio of collagen to elastin within the arterial wall has been used to determine the relative distensibility of an artery for the maintenance of tension within an arterial wall. The lowest collagen-to-elastin ratio is found in the proximal lower limb arteries. In addition, it has been documented that elastic arteries are known to distribute drugs more efficiently.

An elastic artery may take up more drug than muscular arteries. Experiments show that the drugs metabolized by the liver will preferentially localize within the elastin sheath thereby creating locally high concentrations of the drug. If endothelial integrity is lost under circumstances of protracted vasoconstriction there will be loss of protection for the vascular smooth muscle and hence the potential for relapse especially during the early phase of recovery.

Ergotism is a reversible condition.

Ergot Ergotism

Therefore, if diagnosed and treated quickly, irreversible ischemia can be avoided. Management therefore involves discontinuation of the ergot and other potential vasoconstrictors, and eryotism use of vasodilators, anticoagulants, and consideration of endovascular procedures.

As with our patient, we would routinely recommend antithrombotic prophylaxis because of the increased risk of arterial thrombotic complications predisposed by the vessel wall spasm and endothelial injury. Peripheral balloon angioplasty and other interventions may be indicated; however, vascular injury is a potential complication of any invasive procedure under these circumstances.

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Furthermore, intervention by angioplasty in the acute phase would be expected to fail because clinical experience indicates that there is an increased risk of recurrent spasm of the affected arterial segments during the acute phase of ergotism. In this case, duplex ultrasonography was the diagnostic imaging modality with serial ultrasound studies directing ongoing management and enabling close surveillance of the vascular status.

This case highlights specific findings seen with this disease process using duplex ultrasonography. There is selective involvement of the external iliac arteries with segmental and smooth concentric vasoconstriction and other features of a nonatherosclerotic process, including the absence of calcification. The reversibility of ergotism is confirmed; however, there is the potential for relapse related to the loss of endothelial integrity.

This could also predispose to thrombotic complications. Both the noninvasive nature and the absence of radiation exposure for the patient and the technician make duplex ultrasonography the preferred imaging modality for the rapid diagnosis and management of nonatherosclerotic vascular disorders such as ergotism. National Center for Biotechnology InformationU. Journal List Int J Angiol v. Published online Feb 9. Author information Copyright and License information Disclaimer.

Address for correspondence Claudia A. This article has been cited by other articles in PMC. Abstract A case of ergotism is presented to illustrate the role of duplex ultrasonography in the diagnosis and management of this nonatherosclerotic cause of peripheral arterial disease.

Case Report A year-old female patient presented with a month history of classical severe lower limb symptoms of intermittent claudication. Open in a separate window. Discussion Ergot is the more common name of the sclerotia of a fungal species, from within the genus of Claviceps purpureawhich produces ergot alkaloids.

Conclusion In this case, duplex ultrasonography was the diagnostic imaging modality with serial ultrasound studies directing ongoing management and enabling close surveillance of the vascular status.

Fatal ergotism induced by an HIV protease inhibitor. Enge I, Sivertssen E. Ergotism due to therapeutic doses of ergotamine tartrate. Laboratory studies on the outbreak of Gangrenous Ergotism associated with consumption of contaminated barley in Arsi, Ethiopia.

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Ergotism caused by concurrent use of ritonavir and ergot alkaloids: Report of two cases and review of the literature.

Ergotism, arteriospastic disease and recovery, studied angiographically. Severe peripheral ischaemia during concomitant use of beta blockers and ergot alkaloids. Acute myocardial infarction secondary to ergot therapy. N Engl J Med. Noninvasive method for recognition of coronary artery spasm: Arteriospasm after overdose of oral ergotamine tartrate in migraine.

Ergot intoxication in a young woman qnd migraine case report W V Med J. Severe facial ischaemia ergotusm by ergotism. J Cardiovasc Surg Torino ; 33 3: A complication nad migraine therapy. Fedotin M S, Hartman C. Ergotamine poisoning producing renal arterial spasm. Mesenteric and peripheral vascular ischemia secondary to ergotism.

Nov 11 — Ergotamine-induced lower extremity arterial vasospasm presenting as acute limb ischemia.

Collagen and elastin content in canine arteries selected from functionally different vascular beds.