Sample records for doxorrubicina liposomal pegilada . By modulating the liposomal membrane, liposomes can become sensitive towards enzymatically- driven. Pages CARTAS CIENTÍFICO-CLÍNICAS. DOI: /S(09) Erupción intertriginosa por doxorrubicina liposomal pegilada. Visits. Year/Month, Html, Pdf, Epub, Total. November, 2, 0, 0, 2. October, 22, 0, 0, September, 4, 0, 0, 4. August, 0, 1, 0, 1. July, 0, 0, 0, 0.

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Liposomal doxorubicin is used for the treatment of various cancers like epithelial ovarian cancers, multiple myeloma and sarcomas. We report the first case of anaphylaxis to pegylated liposomal doxorubicin. Reportamos ;egilada primer caso de anafilaxia a la doxorrubicina liposomal pegilada. Anaphylaxis is a clinical diagnosis and is an unexpected, non-dose related adverse drug reaction 1.

We describe the first reported case of anaphylaxis to liposomal doxorubicin. A year old female with metastatic primary pulmonary monophasic synovial sarcoma presented for the first cycle of chemotherapy. She denied any chest pain, shortness of breath, cough or palpitations.

Her past medical history included hypertension, hypercholesterolaemia, hypertriglyceridaemia, diabetes mellitus, parkinsonism, osteopaenia, gastroesophageal reflux disease, bipolar disorder, glaucoma and arthritis of the hip doxorrubjcina. Her surgical history included laparoscopy, hysterectomy, carpal tunnel release, aortoileofemoral bypass graft, aortic valve replacement and laminectomies.


Systemic examination revealed tremors that were related to parkinsonism. Laboratory data showed normal blood counts and normal liver and renal function. Prior to the administration of the first dose of chemotherapy, she was premedicated with 20 mg of dexamethasone. Twelve minutes after starting the infusion, the patient developed shortness of breath, flushing, feeling warm and dizziness.

The patient’s condition improved over the next 40 minutes and she was discharged in a stable condition. The common toxicities of liposomal doxorubicin include palmar-plantar erythrodysesthesia, myelosuppression, stomatitis and cardiac toxicity 2. Hypersensitivity reaction is not a common side effect of doxorubicin 3. However, in various studies using liposomal doxorubicin, 4—7.

It has been postulated that serious hypersensitivity reaction is due to the surface component of the liposome itself and not the actual drug. The mechanism of anaphylactoid reaction is probably due to complement activation and not IgE mediated type I allergy 56. The reactions occur typically during the first infusion.

Clinical trials

To the best of our knowledge, this is the first reported case of anaphylaxis from liposomal doxorubicin. It is important for healthcare providers to be aware of this potentially fatal side effect.

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Early recognition and prompt intervention may prevent life-threatening complications.

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Single photocopies may be made by individuals without obtaining prior permission. Abstract Liposomal doxorubicin is used for the treatment of various cancers like epithelial ovarian cancers, multiple myeloma and sarcomas.

doxorrubicina liposomal pegilada: Topics by

Janssen Products, LP; Drug Intell Clin Pharm. Phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in progressive or recurrent ovarian cancer.

Role of complement activation in hypersensitivity reactions to Doxil and hynic PEG liposomes: Support Center Support Center. Please review our privacy policy.